Winlevi (clascoterone cream 1%) is a newer treatment for acne that works by blocking skin receptors that respond to male hormones (androgens).
Androgens, specifically hormones like testosterone and dihydrotestosterone (DHT), act as the "on switch" for the skin's sebaceous glands.
Previous, the only way to block this hormonal cascade was through tablet medications like spironolactone or the combined contraceptive pill. While effective, these medications alter hormones throughout the entire body and are only suitable for female patients.
Winlevi blocks androgen receptors directly within the skin where it is applied. When rubbed into the skin. This reduces oil production and inflammation. Winlevi does not enter the bloodstream significantly or cause systemic hormonal side effects. This makes it a suitable treatment for both men and women suffering from acne.
Winlevi is typically prescribed to be applied twice daily to clean, dry skin. While highly effective, it can cause mild local side effects, including temporary redness, itching, scaling, or dryness at the application site. It is often prescribed alongside other treatments, such as topical retinoids, for a comprehensive acne strategy.
